Experimental Infection of Naegleria fowleri in Mice
نویسندگان
چکیده
منابع مشابه
Innate resistance of mice to experimental infection with Naegleria fowleri.
The mouse system provides an excellent model for studying host resistance to Naegleria fowleri, the agent of primary amoebic meningoencephalitis. Innate resistance to infection with N. fowleri was examined with respect to infecting dose and the age, sex, and strain of mice. Intravenous inoculation with 10(7) amoebae per mouse produced 100% mortality in 9 days, whereas inoculation with fewer amo...
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Naegleria fowleri produced fatal meningoencephalitis in mice following intravenous (i.v.) inoculation. Amebae were present in the peripheral circulation for 120 minutes after i.v. inoculation with a dose of 10(7) trophozoites per mouse. Amebae were cultured from and observed in brain (days 1-21), lung (days 1-12), and liver and kidney (days 1-5). Infected mice exhibited weight loss, leukocytosi...
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Between 1988 and 2003, Naegleria fowleri was studied extensively in Thailand. The distribution of N. fowleri has been studied in many provinces since 1988. During 2001-2003, we received financial support from Mahidol University to study the distribution of pathogenic Naegleria spp in water reservoirs in central, northern, and western parts of Thailand. With these funds, research was conducted i...
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ژورنال
عنوان ژورنال: Journal of the Japanese Association for Infectious Diseases
سال: 1998
ISSN: 1884-569X,0387-5911
DOI: 10.11150/kansenshogakuzasshi1970.72.1064